The urease enzyme in people converts urea, most often found in urine, into ammonia. This can cause a range of issues. In children nappy rash is a direct cause of this reaction. In adults, the urease enzyme has also been implicated in the survival of H.Pylori, a pathogen often found in the stomach which can lead to gastritis, reflux and potentially dangerous ulceration.
This project aims to isolate, classify and reproduce naturally occuring urease inhibitors from fruits which may lead to a natural cure for these ailments. The work will be led by Dr Kyle Stewart at Torbay Hospital working with the University of Exeter.